致力于研究感染与炎症性疾病中的天然免疫应答及核心代谢重编程机制。通过系统解析关键分子和信号通路的调控网络，阐明疾病发生与进展的分子机制，为新型干预靶点和治疗策略的开发奠定基础。主要研究方向包括：
Tong Z, Zou JP, Wang SY, Luo WW*, Wang YY*.(2024) Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons Contributes to Host Defense.Adv Sci. 2024 Sep;11(35):e2308890.
Luo WW, Tong Z, Cao P, Wang FB, Liu Y, Zheng ZQ, Wang SY, Li S, Wang YY*. (2022) Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes.Nat Commun.2022 Aug 16;13(1):4822.
Zhang, H.Y., Liao, B.W., Xu, Z.S., Ran, Y., Wang, D.P., Yang, Y., Luo, W.W*., and Wang, Y.Y*. (2020). USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA. PLoS Pathog 16, e1008178.
Cao, P., Luo, W.W*., Li, C., Tong, Z., Zheng, Z.Q., Zhou, L., Xiong, Y., and Li, S*. (2019). The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLoS Pathog 15, e1007983.
Luo, W.W., and Shu, H.B. (2018). Delicate regulation of the cGAS-MITA-mediated innate immune response. Cell Mol Immunol 15, 666-675.
Luo, W.W., and Shu, H.B. (2017). Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses. FEBS Lett 591, 3182-3189.
Luo, W.W., Li, S., Li, C., Zheng, Z.Q., Cao, P., Tong, Z., Lian, H., Wang, S.Y., Shu, H.B., and Wang, Y.Y. (2017). iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLoS Pathog 13, e1006693.
Luo, W.W., Li, S., Li, C., Lian, H., Yang, Q., Zhong, B., and Shu, H.B. (2016). iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol 17, 1057-1066.
Luo, W.W., Lian, H., Zhong, B., Shu, H.B., and Li, S. (2016). Kruppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol 13, 65-72.
