致力于细胞抗病毒天然免疫信号转导机制与细胞代谢调控的研究，利用细胞生物学、分子生物学、代谢组学、免疫学和病毒学等相关技术深入研究病毒感染诱导I型干扰素产生的分子机制，以及病毒感染、免疫应答与细胞代谢之间相互调控的分子机制，为发展有效的抗病毒药物的开发提供策略。
Hu, M.M.*; He, WR; Gao, P; Yang, Q; He, K; Cao, L.B.; Li, S.; Feng, Y.Q.; Shu, H.B.*, Virus-induced accumulation of intracellular bile acids activates the TGR5-b-arrestin-SRC axis to enable innate antiviral immunity, Cell Research. 2019.1.16, 1(1): 1~13
Hu, M.M.* and Shu, H.B.*, Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids. Annual Review of Cell and Developmental Biology. 2018.8.2, 34(1): 1~23
Yang, Q., Liu, T.T., Lin, H., Zhang, M., Wei, J., Luo, W.W., Hu, Y.H., Zhong, B., Hu, M.M.*, and Shu, H.B*. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog. 2017. 13(9):e1006600.
Hu, M.M., Liao, C.Y., Yang, Q., Xie, X.Q., and Shu. H.B. Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med. 2017. 214(4):973-989.
Hu, M.M. and Shu HB. Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell Mol Immunol. 2017. 14(4):331-338.
Hu, M.M., Yang, Q., Xie, X.Q., Liao, C.Y., Lin, H., Liu, T.T., and Shu, H.B. Sumoylation promotes the satbility of the DNA sensor cGAS and the adaptor STING to regulate the kinetics of response to DNA virus. Immunity. 2016. 45, 555-569.
Hu, M.M., Xie, X.Q., Yang, Q., Liao, C.Y., Ye, W., Lin, H., and Shu, H.B. TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol. 2015. 195, 4415-4425.
Hu, M.M., Yang, Q., Zhang, J., Liu, S.M., Zhang, Y., Lin, H., Huang, Z.F., Wang, Y.Y., Zhang, X.D., Zhong, B., and Shu, H.B. TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014. 111, 1509-1514.
