教育经历

1996.09-1999.07    湖南医科大学，内科/传染病学，博士

1992.09-1995.07    湖南医科大学，医学微生物学，硕士

1983.09-1988.07    湖南医科大学，临床医学，学士

工作经历

2015.04-至今          中国科学院大学岗位教授

2014.01-2019.12    中国科学院脑科学和智能技术卓越中心，首批特聘研究员

2009.07-至今          中国科学院武汉病毒研究所，研究员(百人计划）

2008.01-2010.10    University of Idaho，Microbiology，Assistant Professor

2004.12-2007.12    University of Idaho，Microbiology，Research Scientist

2002.08-2004.11    中南大学，湘雅医学院，教授

2000.04-2002.08    Harvard Medical School，E.K. Shriver Center，博士后

1988.07-2000.11    中南大学（湖南医科大学），助教/副教授

学术兼职

Journal of Virology编委；

Virologica Sinica 编委；

加州大学Irvine分校访问教授。

研究内容

主要从事嗜神经疱疹病毒（HSV、CMV、VZV）的基础和应用研究。包括：1）构建工具病毒，建立可视化感染模型，解析嗜神经疱疹病毒致神经损伤机制。2）改造病毒：研发神经环路示踪工具（产业化）；研发新型疫苗（公司合作）；研发溶瘤和基因治疗大容量病毒载体。

主持项目

1. 国家自然科学基金重点项目

   项目名称：先天性CMV脑感染-脑损伤/钙化的时空特征与机制

   资助金额：299万元

   
   

2. 国家重点研发计划项目

   课题名称：新型工具病毒和可视化感染模型的构建及应用

   资助金额: 390万元

   
   

3.  国家自然科学基金国际合作重点

   课题名称：先天性巨细胞病毒感染下调Sox2影响胎脑发育的机制

   资助金额：286.50万元

   
   

4. 国企合作项目

   课题名称：新型水痘疫苗合作研发

   资助金额：5088.5万元

   
   

5. 国家自然科学基金面上项目

   课题名称: HCMV-IE1下调Cx43致听力损伤机制

   资助金额：72.80万元

   
   

6. 美国NIH RF01项目

   课题名称：Genetically engineered anterograde monosynaptic viral tracers for multi-species neural circuit analysis.

   资助金额：67万美元

   
   

7. 武汉市重点研发计划

   课题名称：HSV-1扩增子载体高效递送天然胶原蛋白的美容产品研发

   资助金额：130万元

   
   

8.  省重点研发计划

   课题名称：通过确诊新生儿的先天性CMV感染阻断后遗症和防止严重后遗症研究

   资助金额：20万元

成果（限10篇）#并列第一作者，*通讯作者）

1. Feng Xiong^#, Hong Yang^#, Yi-Ge Song, Hai-Bin Qin, Qing-Yang Zhang, Xian Huang, Wei Jing, Manfei Deng, Yang Liu, Zhixiang Liu, Yin Shen, Yunyun Han, Youming Lu, Xiangmin Xu, Todd C Holmes, Minmin Luo, Fei Zhao*, Min-Hua Luo*, Wen-Bo Zeng* . An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing. Nat Commun. 2022 Dec 10;13(1):7645.

2. Xian-Zhang Wang^#, Le Wen^#, Yue-Peng Zhou, Sheng-Nan Huang, Bo Yang, Shuang Cheng, Wen-Bo Zeng, Meng-Jie Mei, Jin-Yan Sun, Xuan Jiang*, Han Cheng*, Min-Hua Luo*. Human cytomegalovirus pUL97 upregulates SOCS3 expression via transcription factor RFX7 in neural progenitor cells. PLoS Pathog. 2023 Feb 8;19(2):e1011166. doi: 10.1371/journal.ppat.1011166.

3. Le Wen^#, Xian-Zhang Wang^#, Yong Qiu, Yue-Peng Zhou, Qing-Yang Zhang, Shuang Cheng, Jin-Yan Sun, Xing-Jun Jiang, Simon Rayner, William J. Britt, Jian Chen, Fei Hu*, Fang-Cheng Li*, Min-Hua Luo*, Han Cheng*. SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells. PLoS Pathog. 2023 Apr 14;19(4):e1011316. doi: 10.1371/journal.ppat.1011316.

4. Yue-Peng Zhou, Meng-Jie Mei, Xian-Zhang Wang, Sheng-Nan Huang, Lin Chen, Ming Zhang, Xin-Yan Li, Hai-Bin Qin, Xiao Dong, Shuang Cheng, Le Wen, Bo Yang, Xue-Fang An, Ao-Di He, Bing Zhang, Wen-Bo Zeng, Xiao-Jun Li, You-ming Lu, Hong-Chuang Li, Haidong Li, Wei-Guo Zou, Alec J. Redwood, Simon Rayner, Han Cheng, Michael A. McVoy, Qiyi Tang, William J. Britt*, Xin Zhou*, Xuan Jiang*, Min-Hua Luo*. A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment. JCI Insight. 2022 Jan 11;7(1):e152551. doi: 10.1172/jci.insight.152551.

5. Le Wen, Fei Zhao, Yong Qiu , Shuang Cheng, Jin-Yan Sun, Wei Fang , Simon Rayner , Michael A McVoy, Xing-Jun Jiang, Qiyi Tang, Fang-Cheng Li*, Fei Hu*, Min-Hua Luo*. Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis. Protein Cell. 2020 Sep 15. doi: 10.1007/s13238-020-00787-7.

6. Hong Yang^#, Feng Xiong^#, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng*, Fei Zhao*, Min-Hua Luo*. A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling. Molecular Neurodegeneration. 2022 Jan 10;17(1):6.

7. Wen-Bo Zeng^#, Hai-fei Jiang^#, Ya-Dong Gang, Yi-Ge Song, Zhang-Zhou Shen, Hong Yang , Xiao Dong, Yong-Lu Tian, Rong-Jun Ni, Yaping Liu, Na Tang, Xinyan Li, Xuan Jiang, Ding Gao, Michelle Androulakis, Xiao-Bin He, Hui-Min Xia, Ying-Zi Ming, Youming Lu, Jiang-Ning Zhou, Chen Zhang, Xue-Shan Xia, Yousheng Shu, Shao-Qun Zeng, Fuqiang Xu , Fei Zhao, Min-Hua Luo*. Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129. Mol Neurodegener. 2017; 12:38.

8. Xi-Juan Liu^#, Bo Yang, Sheng-Nan Huang, Cong-Cong Wu, Xiao-Jun Li, Shuang Cheng, Xuan Jiang, Fei Hu, Ying-Zi Ming, Michael Nevels, William J Britt, Simon Rayner, Qiyi Tang, Wen-Bo Zeng, Fei Zhao, Min-Hua Luo *. Human Cytomegalovirus IE1 Downregulates Hes1 in Neural Progenitor Cells as a potential E3 Ubiquitin Ligase. PLoS Pathog. 2017; 13(7):e1006542.

9. Bo Yang^#, Yong-Xuan Yao ^#, Han Cheng ^#, Xian-Zhang Wang, Yue-Peng Zhou, Sheng-Nan Huang, Xuehui Ma , Hong Yang, Jinpeng Wu, Xuan Jiang , Shuang Cheng, Jin-Yan Sun, Wen-Bo Zeng , Jason Chen, Fu-Kun Zhang , Hong-Jie Shen, Jian-Yang Gu, Michael A McVoy , William J Britt*, Sitang Gong*, Min-Hua Luo*. Human Cytomegalovirus Hijacks WD Repeat Domain 11 for Virion Assembly Compartment Formation and Virion Morphogenesis. J Virol. 2022 Mar 9;96(5):e0182721. doi: 10.1128/JVI.01827-21.

10. Sheng-Nan Huang, Yu-Ting Pan, Yue-Peng Zhou, Xian-Zhang Wang, Meng-Jie Mei, Bo Yang, Dong Li, Wen-Bo Zeng, Shuang Cheng, Jin-Yan Sun, Han Cheng*, Fei Zhao*, Min-Hua Luo*. Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43. J Virol. 2023 May 31;97(5):e0031323. doi: 10.1128/jvi.00313-23.

奖励

2022和2023年：国科大研究生优秀课程奖《病毒病与监控》；

2016年：湖南省技术发明一等奖；

2015年：朱李月华教师奖；

2013年：教育部自然科学二等奖。