重点开展虫媒新病原的发现、预警预测与生物安全研究,新分离鉴定蚊、蠓来源虫媒病毒近20种,完成新发虫媒病毒Ebinur Lake virus、Oya virus等的感染传播风险评估;创建首个我国蚊虫与病毒、全球虫媒病毒多样性和生物安全分级综合数据集及AI辅助的知识-数据突破;建立虫媒生物安全二级(ACL-2)实验室,牵头起草并发布医学节肢动物现场和实验室生物安全规范专家共识与省级地方标准等。
Xiaoyu Wang#, Ying Huang#, Fei Wang, Qianyun Hu, Doudou Huang, Haixia Ma, Yi Liu, Qiyong Liu, Bo Zhang, Zhiming Yuan*, Han Xia*. DENV-2 3′UTR dumbbell structure is a critical factor for viral infection and dissemination in Aedes mosquito. Journal of Virology, 2025: e0075825.
Qun Wu#, Dingwei Sun#, Wahid Zaman, Fei Wang, Doudou Huang, Haixia Ma, Shunlong Wang, Ying Liu, Puyu Liu, Xuexia Zeng, Zhiming Yuan*, Han Xia*. Detection and evolutionary characterization of arboviruses in mosquitoes and biting midges on Hainan Island, China, 2019–2023. PLoS Neglected Tropical Diseases, 2024, 18(10): e0012642.
《生物安全导论》中国科学院大学研究生教材/科学出版社十四五高等教育研究生规划教材,主编:袁志明,夏菡,2024,科学出版社.
Zhiqiang Li#, Han Xia#, Guibo Rao#, Yan Fu, Tingting Chong, Kexing Tian, Zhiming Yuan*, Sheng Cao*. Cryo-EM structures of Banna virus in multiple states reveal stepwise detachment of viral spikes. Nature Communications, 2024, 15:2284.
Nanjie Ren#, Qianqian Jin#, Fei Wang, Doudou Huang, Cihan Yang, Wahid Zaman, Ferdinand Villanueva Salazar, Qiyong Liu, Zhiming Yuan*, Han Xia*. Evaluation of vector susceptibility in Aedes aegypti and Culex pipiens pallens to Tibet orbivirus. mSphere, 2024,9(4):e0006224.
Ying Huang#, Shunlong Wang#, Hong Liu#, Evans Atoni, Fei Wang, Wei Chen, Zhaolin Li, Sergio Rodriguez, Zhiming Yuan, Zhaoyan Ming*, Han Xia*. A global dataset of sequence, diversity and biosafety recommendation of arbovirus and arthropod-specific virus. Scientific Data, 2023, 10:305.
Zhaoyan Ming, Xiangjun Chen, Shunlong Wang, Hong Liu, Zhiming Yuan, Minghui Liu*, Han Xia*. HostNet: Improved Sequence Representation in Deep Neural Network for Virus-Host Prediction. BMC Bioinformatics, 2023,24:455.
Nanjie Ren#, Fei Wang#, Lu Zhao, Shunlong Wang, Guilin Zhang, Jiaqi Li, Bo Zhang, Jinglin Wang, Eric Bergeron, Zhiming Yuan*, Han Xia*. Efficient rescue of a newly classified Ebinur lake orthobunyavirus with GFP reporter and its application in rapid antiviral screening. Antiviral Research, 2022, 207: 105421.
Cihan Yang#, Fei Wang#, Doudou Huang, Haixia Ma, Lu Zhao, Guilin Zhang, Hailong Li, Qian Han, Dennis Bente, Ferdinand Villanueva Salazar, Zhiming Yuan*, Han Xia*. Vector competence and immune response of Aedes aegypti for Ebinur Lake virus, a newly classified mosquito-borne orthobunyavirus. PLOS Neglected Tropical Disease, 2022, 16(7): e0010642.
Evans Atoni#, Lu Zhao#, Cheng Hu, Nanjie Ren, Xiaoyu Wang, Mengying Liang, Caroline Mwaliko, Zhiming Yuan*and Han Xia*. A dataset of distribution and diversity of mosquito-associated viruses and their mosquito vectors in China. Scientific Data, 2020,7:342.