教育经历

2008.09-2012.07    中国科学院武汉病毒研究所，研究生，博士学位

2004.09-2007.06    华中农业大学，研究生，硕士学位

2000.09-2004.06    河北农业大学，本科，学士学位

工作经历

2018.02-至今          武汉病毒研究所武汉国家生物安全实验室

学术兼职

第二届动物实验生物安全专业委员会委员

研究内容

本人主要从事新发再发传染病动物感染模型的研究，以及基于动物模型进行相关药物和疫苗的评价等工作。涉及的病原包括中东呼吸综合征病毒、流感病毒、新冠病毒、尼帕病毒、埃博拉病毒、拉沙病毒、克里米亚刚果出血热病毒等。

主持项目

1. 国家自然科学基金面上项目

   项目名称：尼帕病毒广谱疫苗免疫原的优化和免疫保护机制探讨

   资助金额：230000人民币

   
   

2. 国家重点研发计划项目

   课题名称: 寒湿疫方治疗新冠肺炎作用机制的国际合作研究

   资助金额: 910000人民币

成果（限10篇）#并列第一作者，*通讯作者）

1. Lu M#, Yao Y#, Liu H, Peng Y, Li X, Gao G, Chen M, Zhang X, Mao L, Yang P, Zhang X, Miao J, Yuan Z, Lan J*, Shan C*. Single-dose intranasal AdC68-vectored vaccines rapidly protect Syrian hamsters against lethal Nipah virus infection. Mol Ther. 2025, 33(7):3270-3285.

2. Zhou J#, Zhang X#, Yao Y#, Xie Y, Li F, Wang W, Yan F, Peng C, Zhang B, Wu Y, Cao Z, Peng Y, Gao G, Zhang H*, Gong P*, Chiu S*. Recombinant live attenuated measles virus-based vaccines inducing comprehensive protection against Ebola and Marburg viruses. Mol Ther. 2025, S1525-0016(25)00652-5

3. Chen S#, Zhang X#, Yao Y#, Chuai X#, Li K, Zhang B, Ye T, Wu Y, Ran Y, Chen L, Wang S, Wang W, Gong R, Zhang H*, Chiu S*. An Intein-Spliced Nipah G Protein Ferritin Nanoparticle Vaccine Provides Complete Protection against Lethal Nipah Virus Challenge. ACS Nano. 2025, 19(23):21319-21332.

4. Chen L#, Sun M#, Zhang H#, Zhang X#, Yao Y#, Li M, Li K, Fan P, Zhang H, Qin Y, Zhang Z, Li E, Chen Z, Guan W, Li S, Yu C*, Zhang K*, Gong R*, Chiu S*. Potent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains. Nat Commun. 2024, 15(1):2987.

5. Lu M#, Yao Y#*, Liu H, Zhang X, Li X, Liu Y, Peng Y, Chen T, Sun Y, Gao G, Chen M, Zhao J, Zhang X, Yin C, Guo W, Yang P, Hu X, Rao J, Li E, Wong G, Yuan Z*, Chiu S*, Shan C*, Lan J*. Vaccines based on the fusion protein consensus sequence protected Syrian hamster from nipah virus infection. JCI Insight. 2023, 8(23):e175461.

6. Lu M#, Yao Y#*, Zhang X, Liu H, Gao G, Peng Y, Chen M, Zhao J, Zhang X, Yin C, Guo W, Yang P, Hu X, Rao J, Li E, Chen T, Chiu S, Wong G, Yuan Z*, Lan J*, Shan C*. Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection. NPJ Vaccines. 2023, 8(1):170.

7. Lu M#, Liu K#, Peng Y#, Ding Z#, Li Y, Tendu A, Hu X, Gao G, Guo W, Liu H, Rao J, Zhao J, Chen M, Yuan Z, Wong G^#, Shan C^*, Yao Y^*, Lan J^*. Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice. Virol Sin. 2022, S1995-820X(22)00095-5.

8. Yao YF#, Wang ZJ#, Jiang RD#, Hu X#, Zhang HJ#, Zhou YW, Gao G, Chen Y, Peng Y, Liu MQ, Zhang YN, Min J, Lu J, Gao XX, Guo J, Peng C, Shen XR, Li Q, Zhao K, Yang L, Wan X, Zhang B, Wang WH, Wu J, Zhou P, Yang XL*, Shen S*, Shan C*, Yuan ZM*, Shi ZL*. Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates. Virol Sin. 2021, 36(5):879-889.

9. Shan C#^*, Yao YF#, Yang XL#, Zhou YW#, Gao G, Peng Y, Yang L, Hu X, Xiong J, Jiang RD, Zhang HJ, Gao XX, Peng C, Min J, Chen Y, Si HR, Wu J, Zhou P, Wang YY, Wei HP, Pang W, Hu ZF, Lv LB, Zheng YT, Shi ZL*, Yuan ZM*. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. Cell Res. 2020, 30(8):670-677.

奖励

2021年获得全国科技系统抗击新冠肺炎疫情先进个人